693
KLINICKÁ341804301074588109168189242288347
FARMAKOLOGIE708804301074392139212266313373416475534555599
A13288043010753
FARMACIE1402804301074292139211266317337381
/18048043010757
Klin1880804301077091109157
Farmakol2057804301074278105179220258305325
Farm2402804301074178104179
2022;36(1):24-282601804301074386128172187231275298338355370414454483522565
/31858043010777
www.klinickafarmakologie.cz4568804301076513320121425327329234035839843647950254457164568672477179183988990895196610061045
281838026012657115
HLAVNÍ341207012670127198263336370
TÉMA732207012658115205275
Antifibrinolytika34136501063879111129159177213249266307348380412447464500542
a898365010638
jejich951365010623558299134175
použití114136501063475116148165197215
v1371365010637
kardiochirurgii142336501063476112152169210245286304339380415455472489
LITERATURA34458001234978134189250318368438498567
1.3437400853648
Penka4067410833467105136169
M.5907410835367
Fyziologie673741083306192108146162200239254289
krevního977741083285185117156171210249
srážení.1241741083254679108142180195208
In:1464741083145264
Penka15437410833467105135169
M,17277410835366
Penka18097410833367105135169
I,19937410831326
Gumulec3438410834482140177193227260
J61884108325
et6588410833456
al.729841083324861
Krvácení.805841083355792125157191229244257
Praha:1077841083355689127159172
Grada;2014.1264841083446598137169182217251282314326
p.16058410833952
27-31.1672841083346786118149158
2.3439400853652
Levy409941083326698133
JH.557941083246983
Antifibrinolytic6559410834179101116134151190211227265303319351376391423
therapy.1093941083226095117150189220230
New13389410834580131
data1485941083387092125
and16259410833270109
new17509410833873124
concepts.1889941083326810734310410833165104126154168
Lancet52610410833165103135169191
2010;376:3-4.73210410833468100132144179212244256291313350362
3.34311400853651
Hájek4081141083427490124155
R,57811410833347
Zezula6401141083366999137152185
R,84011410833347
Fluger9021141083304582121156177
I,109511410831225
et113511410833254
al.12041141083304558
Význam12771141083346697136168226
tromboelastografie151811410831941781361752142502652983243473844244454783431241083173468
pro4261241083355693
monitorování53412410835492130144166203224260292324361376
hemostázy92512410833569126164190213245274307
v1247124108329
kardiochirurgii.12911241083265980118132170202239254274312333370385400412
Interv17181241083124971104124159
Akut189112410833868106128
Kardiol3431341083356890128143181197
2005;4(4):224-228.55513410833468105139149184204237254266301336368391422456490503
4.34314400853651
Hájek4091441083508298133163
R,58714410834155
Růžičková65814410834078107123155185222254287
J,96114410832941
Gwozdziewicz1018144108349100138166204234249284336351383414
M,144814410836073
et153614410834062
al.16141441083375265
Hodnocení169414410835088128166205237271310325
funkce3431541083195998129161196
trombocytů5551541083285089149189229263298323362
během93315410834582121157217
mimotělního116615410836480139179202236253292307348388
oběhu157015410834384121160199
pomocí178515410834585145184218234
tromboelastografie.3431641083224380139178217252268300327350387426447480498515550562
Cardiol9201641083407394132147185201
2006;15(2):78-88.113716410833468104140152182212230264282294327360383419454468
5.34317400853753
Royston41317410834283117146171211251
D.68217410835366
Haemostasis76517410835287124185225254280315343360389
management.1171174108365100140175216254314352392416431
In:16201741083216276
Alston17131741083496694120159200
RP,19301741083438288
Myles34318410835487105141169
PS,5291841083367185
Ranucci63118410833670110149182214231
M879184108355
et.9511841083355974
al.10411841083335065
Oxford112218410834982104143166206
textbook13441841083235891117158198238270
of163118410833859
cardiothoracic170718410833267891291451852082482873431941083215690107141
anaesthesia.50119410833979113150179204245282310327361376
Oxford:89419410835588111151174215229
Oxford114019410835488111151174214
Univesity137119410835191108143179208224249285
Press;167319410834264101129158172
2015.186219410834177111143157
p.34320410833953
181-191.41220410833668102122154185219230
6.34321400853652
Koster41021410834178105128162184
A,60921410834761
Faraoni6852141083386789122160199214
D,91521410835061
Levy99221410833671103138
JH.11452141083297588
Antifibrinolytic124921410834684106121139156195217233271309326357382398430
therapy169521410832665100121155194225
for19362141083236183
cardiacsurgery:3432241083316484122137169201228265286324358379413426
an78422410832967
update.86622410833574113145166200212
Anesthesiology.109322410833876111137160198232259274311327365404436445
2015;123:214-212.15542241083316596126137166196230242276308338361392423452465
7.34323400853544
Primm4012341083325268124181
AN.5972341083388295
Fibrinolysis,7072341083304482103119156193209240266281306319
antifibrinolytic10412341083286687102119136174195210247285300331355370402
agents145723410832968102139160187
and165923410832966105
perioperative17782341083367192107144183218343244108321547591123158
consideration.51624410832966104131146184219241274295311349387400
In:9322441083125063
Scher101024410833063101136157
CS,11822441083387285
Kaye12822441083336797132
AD,14292441083398596
Liu15402441083304582
H1638244108342
et169524410833254
al.17652441083304558
Essentials18382441083315885120158343254108322376984110
of46925410833958
bloodproduct5432541083415795133173212234271311348380404
management96325410835992130162201236294329367389
in136725410831755
anesthesia143725410833472107134157195230257272304
practice17562541083416396128152167199233
.2004254108315
Cham:34326410834078110168180
Springer5382641083337293109147186221242
Nature;7952641083457799137158192204
2021.101526410833468101132142
p.117226410833951
37-51.12392641083346684118149159
8.34327400853652
Faraoni4102741083316182115153192207
D.63227410834455
Fibrinolytic7032741083314585106122160198214246270286318
system.10362741083255784108141199212
In:12642741083135163
von134327410833068106
Heymann146427410834378110168201239277
C,175627410833951
Boer182327410833472108129
C.196727410833952
Patient3432841083356789104139177198
blood5572841083365290129169
management74128410835588126158197232290325363384
in114128410831250
cardiac12072841083296283121136168200
surgery.14232841083246182120155176210220
Cham:165928410833875108166178
Springer185228410833169911071443432941083387394
Nature;4532941083447798136157192204
2019.67229410833468100130141
p.82929410833851
107-116.8952941083346698117148175206220
9.34330400853649
Royston40730410833573105132155192230
D,65230410834556
Taylor7233041083326091107145167
KM,90530410833491105
Bidstrup10253041083355089115138160198237
BP,12773041083357176
et136830410833355
al.14393041083314659
Effect15143041083325169104137161
of169030410833756
aprotinin17613041083317192129151167204220257
on34331410833775
need43331410833570105145
for5933141083165375
bloodtransfusion6833141083365289128167190211244281307327366392406444482
after11813141083294872106127
repeat13233141083185291126158180
open151831410833574109147
heart168031410833570102123147
surgery.184231410832461821201543433241083215565
Lancet42332410833165103135169191
1987;330:1289-1291.62932410833565100133142177210245258288318351386409440470504536546
10.3433340085356883
Ferraris4403341083296383104136157172197
VA,6523341083337084
Brown7503341083335390140177
JR,9423341083215670
Despotis102733410834276102140178199214239
GJ,12813341083416677
et137333410833152
al.14403341083294456
201115113341083316495122
update164833410833472111142163196
to185933410831955
the19283341083195691
Society34334410833271103119153176209
of56834410833857
Thoracic64134410833373111132165198213245
Surgeons9013441083347192130165204242269
and118534410833371110
the13103441083236196
Society142134410833472105120155177211
of164734410833958
Cardiovascular172034410834174951331491862182512783433541083316984117138
Anesthesiologists49635410833978113139163201236263277315331369409424450473501
blood10123541083385492130170
conservation119735410833067105132167188223256277293331369
clinical1581354108330456098113145178194
practice17903541083375992124148163195229
guidelines.3433641083387691130165180195233268295308
Ann66736410834179117
ThoracSurg79936410833372110132165197231268290328
2011;91(3):944-982.114236410833468100128136171203218252269281316352389412447482515528
11.2138740085366779
Henry22347410834985124145180
DA,24297410835192106
Carless25517410834579100117152179206
PA,2773741083417993
Moxey28827410836099130164196
AJ,3094741083477486
et31967410834062
al.3274741083375366
Anti-fibrinolytic33567410834785107123146164181221243259297336352385410426458
use2138841083376499
for2252841083246183
minimising23508410836378116131189204231245283323
perioperative26888410834479101116155194230251284306322354389
allogenic3092841083375268106145180219234266
bloodtransfusion.33738410834460981371771992212542923193393774044192138941083377689
Cochrane22429410834077110148169202240275
Database25329410834678100132172205231266
SysRev.2007;1:CD001886.2813941083336390125160193203239273309341351381390431476512548580611647682695
12.21381040085366783
Mangano223610410835284122160192230268
DT,25191041083437483
Tudor261710410833063102140161
IC,27931041083125366
Dietzel28741041083425892114144178194
C.308310410833750
Multicenter314810410835289104126142173207244266299320
Study34831041083305188127159
of365710410833453
Perioperative37261041083326521381141083213673113148169201223238270304
Ischemia24571141083123870107142199214246
Research27181141083326793128159180211248
Group;29821141083406299136175187
Ischemia31841141083123870107142199214246
Research34451141083336794128160180211249
and370911410832967105
Education213812410833371108141173195210248287
Foundation.244012410833370109147186218240255293331345
The280012410833372107
risk2923124108321366292
associated30311241083325885123156171203225259298
with33441241083516790128
aprotinin34871241083327193130152167205220258
in376112410831553
cardiac21381341083316485123139171203
surgery.23561341083266385123158179213223
N2594134108345
Engl265413410833371110125
J2794134108324
Med.283413410835489129142
2006;354:353-365.299113410833468105140153188221256268303336369391423458492504
13.21381440085377085
Karkouti22401441083407597128166205228244
K,250014410834156
Beattie257214410834177110132157173209
WS,279614410836498111
Dattilo292314410835285107132148164203
KM,314114410834199113
et327014410834063
al.33491441083375366
A3431144108347
propensity349414410834567105146182221248263286321
score21381541083276098120155
case-control23091541083387299135159194232271294316354371
comparison269615410833775135175209231247274314353
of306515410834464
aprotinin314515410833878100139161177216232271
and343215410833877117
tranexamic35651541083285084123159192226213816410835772104
acid22581641083366984123
in239616410831957
high-transfusion-risk24691641083425796134156179200233271297317356382397435474496518534560590
cardiac30741641083366990128143175207
surgery.32971641083316889127162183217227
Transfusion.3540164108337548712515217221023725121381741083377689
2006;46:327-338.224217410833468105140153187223236271304337355388421455468
14.21381840085366984
Fergusson22381841083326687125163189216254293
DA,25461841083458599
Hebert266018410834479118153175199
PC,28751841083347588
Mazer297818410835486116150171
CD,31651841083398495
et327618410833355
al.33471841083314659
A3422184108340
comparison347718410833168126165198219235261299338
of213819410833757
aprotinin22101941083317091129151166204219257
and248219410833169108
lysine2605194108314467388126161
analogues278119410833169101117155194232267294
in309019410831452
high-risk31571941083375290128151173189215245
cardiac34171941083306384122137169202
surgery.3634194108325628412215721382041083215565
N2218204108345
Engl227820410833370109125
J2418204108324
Med.245820410835489129142
2008;358:2319-2331.261520410833468104140152187220254267302336367398421452487520551560
15.21382140085366883
Maybohm223621410835587118158197235293
P,254521410833539
Herrmann260021410834479100122180213251289
E,290421410833346
Nierhoff29652141083456095116155193213232
J,321221410832436
et326421410833456
al.33352141083324760
Aprotinin341121410834180102139161176214229267
may369321410835890121
increase21382241083155386108142174201237
mortality2391224108363102124149182198213236270
in267722410832058
low275122410832059110
and287722410833776116
intermediate30082241083205981115136196231271287319341376
risk3399224108326426999
but351422410834483106
not363522410834482105
in375522410832059
high21382341083385392130
risk2284234108326416898
cardiac23972341083377091130145177210
surgical26222341083326990129144176209225
patiens286223410834478100115150188215
compared309223410833774133172205227261301
to340823410832765
tranexamic34882341083274982120155187220278294326
acid21382441083326479118
or227124410833859
ε-aminocapronic23462441083305082140155193232264297336358395434449481
acid28422441083326479118
–2975244108336
a3026244108332
meta-analysis307324410835893115148171203241273289320347362388
of347724410833757
randomised35492441083215492131169227242213825410832661101
and225425410833674113
observational238225410834181108143164199231253269307345377393
trials2790254108326476395110136
over294125410834274108129
30,00030852541083387385120157193
patients.32932541083437697113147186207235248
PloSOne,35572541083395492124171210245257
2013;213826410833468100130141
8,3,2295264108334478294
p.e58009.24052641083385186120154190226261272
16.21382740085366985
European22382741083337091128168203235273
Society252727410833271103118153175209
of275227410833756
Anaesthesiology282427410834179112146173196235270296311349365403443475
Task33142741083336188118
Force34472741083337092123156
Report361927410833570109148170195
son213828410832665103
Place22572841083405587119153
of242528410834362
Aprotinin250328410834685107144166182220235273
in279128410832058
Clinical28642841083456176114129161194209
Anaesthesia.308928410834684116151178202240275302317349362
Aprotinin,346728410834685107144166182220235273286
is376828410832046
it213829410831537
time21902941083223795130
to233529410832259
reconsider?24092941083215588125163189204243278299322
Eur27462941083336990
J2852294108324
Anaesthesiol.289129410834179112146173196235270296311349365378
2015;32:591-595.328429410833569100131141176209221257289321340374406440452
17.21383040085367081
Ortmann22363041083477198158193233273
E,252630410833348
Besse259230410833572101130167
MV,277630410835593104
Klein28983041083345390107147
A.306330410834158
Antifibrinolytic313830410834181105122144162203227244284325343377404421455
agents361130410833172109150173203
in213831410831555
current22103141083317194118154194217
anesthesiologic244531410833171108137162203240269285325343384425442476
practice.29393141083386297131157174208244258
BJA.321531410833561103120
2013;111(4):549563.335231410833470104136150182212241258293313327364401436213832410833471106121
18.21383340085366985
Sigaut22393341083365190122159182
S,243633410833649
Tremey25003341083365387145180212
B,272733410833951
Outtara279433410835088111135168189222
A,303133410834559
et310533410833759
al.31803341083355063
Comparison325833410834481139178211232248274312351
of362433410834060
two369933410832578116
doses213834410833979107144172
of232634410834464
tranexamic24073441083285085124161194228288304337
acid27613441083387288128
in290634410832060
patiens298234410834680103119155195223
undergoing322134410834484124161183223263279318359
cardiac35963441083387395135151184218
surgery21383541083276689129165188224
with237835410836279103143
cardiopulmonary25373541083427799139156196237277294354394435469491527
bypass.308135410834982124159187215230
Anesthesiology.332735410835292129157182222259287303343360400442476487
2014;120:590-600.213836410833468100131143173203237250285318353377415450486499
19.3934740085366881
Boer40307410833371106127
C,41727410833750
Meesters42377410835186121147170203224251
MI,4503741083516779
Milojevic4597741083526782119135169201216248
M,48607410835164
et49397410833253
al.5007741083304557
20175079741083326597126
EACTS/EACTA52207410832972110145179203237279318353389
guidelines3934841083387691130165180195233268295
on42448410833978
patient4337841083407395110145183204
blood4557841083405694133172
management47458410835991129161200235293328366388
for5148841083205879
adult52438410833372110125147
cardiac5406841083326586125140172204
surgery.3934941083266384123158179213223
J417294108324
CardiothoracVascAnesth.4212941083407294132147185207245283305338370406438464496539577612639662700714
2017;25:1-34.49419410833468100129139174209220250268301336349
20.39341040085367288
Myles403710410836092108144171
PS,42231041083417487
Smith432510410833896111134173
JA,45131041083307084
Forbes46131041083377597137173200
A,482810410834761
et490510410833961
al.49821041083375366
Tranexamic50631041083385689127163194227286301333
acid54121041083376985124
in555110410832058
patiens39341141083397293109143181208
undergoing415711410834078117152173212250265303342
coronary-artery45141141083357293130169201222256278311332356390411445
surgery.49751141083296687125160182216226
N5216114108348
Engl527911410833673112128
J5422114108327
Med.546411410835893133146
2017;376:136-148.393412410833468100129139174206238251280310345368399430466480
21.39341340085366981
Koster40301341083326995118151172
A,421713410833852
Borgermann42841341083327091129163184241273311348
J,464713410832133
Zittermann4695134108335507296129150207239276314
A,502413410833852
et509113410833152
al.51581341083294457
Moderate523013410835189128162183216237270
dosage55151341083357339341441083265998133
of408314410834160
tranexamic41591441083264780118153185217275290322
acid44971441083366883122
during463414410834380102117155194
cardiac48431441083366990128143175208
surgery50661441083306889127162183217
with52981441083557193132
cardiopulmonary54451441083356889128143393415410833777115130188226265297318352
bypass430215410833970110143169196
and451315410833371110
convulsive463815410833269107138177192218233266300
seizures:49531541083276277106144165199226239
incidence52071541083155385100139174212244278
and550015410833371110
clinical3934164108331476199114146179195
outcome.41441641083377598129166224259271
BJA.443016410833660100115
2013;110(1):34-40.456016410833468100130142172199231250282296308344379402439474487
22.39341740085367490
Kratzer40401741083406397119151185207
S,426317410833851
Irl43301741083204258
H,440417410835063
Mattusch448317410836194116141180207240279
C,477717410834659
et485217410834063
al.49311741083375366
Tranexamic50131741083385690129164197230289304337
acid53661741083377086125
impairs55071741083207939341841083397287108136
gamma-aminobutyric408518410834376134192224247279337352390429468507529563585601633
acid47331841083376985124
receptor48721841083266093127166188225247
type513418410832761101136
A5286184108346
–5347184108340
mediated54031841083629813715218539341941083225595
synaptic40441941083265897129169191206238
transmission42971941083214376114140198213239266280318357
in466919410831452
the47361941083216095
murine484619410835794116131169204
amygdala:506519410833289120159198230245277290
a5370194108331
potential541719410833876981321703934204108322376984
mechanism403420410835893126164196234250276333
for43832041083195779
drug-induced44772041083406199138160176214253291323357396
seizures?48892041083276277106145166200227251
Anesthesiology.515620410834280115142165203238265280318334372412444454
2014;120:639-649.393421410833468100131143173203237250286319353376413450483494
23.39342240085367287
Lecker40372241083316598128162184
I,423622410831427
Wang427822410835889127166
DS,44592241083457891
Romaschin456522410833573131164190223261276314
AD,48942241083408697
et500622410833456
al.50782241083314759
Tranexamic51532241083324982120155187219277292324
acid54932241083316378117
concentrations393423410833167105137170208229250283304319357395421
associated43702341083295582119152166198219253292
withhuman46772341083486385123160197255287324
seizures50162341083245873102140161194221
inhibit52522341083124987102140156178
glycin54452341083355081113127165
receptors.39342441083215587121160182219241268282
J4231244108324
Clin42712441083395570108
Invest.43942441083155384118145168182
2012;122:4651-4666.459124410833468100130142172202237249284320354385403440476512547561
24.39342540085367186
Jerath40352541083245980113135173
A,422425410834054
Yang429425410833464102141
QI,44502541083476275
Pang454025410833567105144
KS,46992541083357083
et479725410833356
al.48682541083314760
Tranexamic49432541083324982120155187220277293325
acid52832541083316379117
dosing541625410833776102117155194
for39342641083195880
cardiac40302641083387294133149182216
surgical42622641083327092132148181215231
patiens450926410834579102118154193220
with47452641083587497137
chronic48982641083377799137177193226
renal514026410832662101134151
dysfunction:53072641083447710512616620523926428039342741083377688
a4037274108332
new408427410833873124
dosing422327410833877103118156195
regimen.44332741083215595110167202241254
AnestAnalg.470227410834179114141164207245278293332345
2018;127:1323-1332.506227410833569100131144174204237247276306339374396426456489522534
25.39342840085367286
Peralta40352841083336586119134156188
R,Thani42382841083334676115146184199
H,Rizoli44522841083415390105134170186201
S.466828410832942
Coagulopathy472528410833774106145182197234273306327365395
in513528410831249
the51992841083195791
surgicalpatient:5305284108324608111913316519721225128339342941083213670107127140
trauma-induced40892941083183971108164196217233269307344375408446
and455029410832966104
drug-induced46682941083355593131152167204242279310343381
coagulopathies.50642941083286496134170185222261293314351365399425438
Current55162941083377239343041083214276115136
Opinion408530410834787103141156194232
in433230410831553
Critical4400304108340617799115147179195
Care.46103041083407394128140
2019;25(6):668-674.476630410833468100130143178213230263282293329364400423460493523536
26.39343140085357086
Gall40353141083417388102
LS,41523141083296275
Davenport424231410834273104138175214252273297
RA.45543141083327489
Fibrinolysis46573141083304483104119156194209240267281307
and497831410832967105
antifibrinolytic50983141083296687102119136174195210247285300332356371402
treatment55153141083194073393432410833254112147185206
in415632410831351
the42223241083205994
trauma43313241083204275112170203
patient.45493241083377092107142180202215
Current47793241083397596118152190212
Opinion500632410834686101139154192231
in525232410831351
Anaesthesiology.5318324108340781111451721952342693934334108326417995133173205215
2018;31(2):227-233.416433410833468100131143178209224258276288323358391409440475508521
27.39343440085367180
Perrault40463441083367091112145183198221
LP,42823441083336873
Moukhariq437034410835694132162202234255271309
FZ.46953441083337184
Fibrin47953441083334887109124162
sealants49723441083286395110142180202229
in521734410831553
cardiac52863441083326586124139171203
surgery.5505344108327648539343541083387394128138
In:40883541083175567
Raja41703541083387186118
SG.43033541083358094
Cardiac44123541083427596134149181214
surgery-46413541083286687125160181215237
a4893354108335
complete494335410833370129168184219241275
guide.52333541083407893132167179
Cham:542735410834381113171183
Springer39343641083327193109146185220242
nature;41913641083377091129151185197
2020.440336410833468101135148
p.456636410833951
119-127.46333641083346292115146176209215
PRAGUE53961540273128257406551702821
SYMPOSIUM5396418027311925243656672584390710581244
2022183064180273124246365486
Polypharmacy5396672019689176216296389480560615750830901983
and15556672019682172264
ageing18526672019681172253294384474
–5396880011045
highly-individualized,603688001105174126179202248276300352405429475499552603650673697737784838860
person-centered14826880011052100133171223275305348394446478524557604657
care2158688001104087120166
October53970860205117193252342437522577
19–21,11527086020587162250328405429
202216177086020587171252337
Prague,539728301335993146207267322343
Czech9067283013364112167217277
Republic12067283013359114177237299325350399
Congress5397423013364122183244280334377420
&9827423013367
Wellness10727423013393145171196256311354397
Hotel14927423013372132168222248
Olšanka17637423013376102144198258309363