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MEDICÍNA3418040010770114173194248268327381
PRO744804001074591153
PRAXI919804001074591148201221
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Med.12628040010770115165181
Praxi.1462804001074671113153172188
2025;22(3):196-2011670804001074386128172185229273294337358372410447492522561604643
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www.medicinapropraxi.cz46688040010765133201214288333383401441460508549598625672722749791831850866906945
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FARMAKOTERAPIE341200012655121184274345411484543600665738800832890
AKTUÁLNĚ1253200012668134196267335390462521
Sukrosomální34136001063171107143183216257311351382424441
železo7983600106316294126161200
–1013360010645
nová107436001063980117154
cesta12443600106326498131167
suplementace142736001063171106137169224256297329366399431
nedostatku187436001063970110151184217253281317358
železa22483600106316394126161202
v2466360010636
těle25183600106306293126
Sukrosomální340930029813026739648962772986610711197126214011465
železo18549300298112238305430543680
–25829300298120
nová27519300298140278400524
cesta33249300298108232336423549
suplementace3922930029810424238545057678290810491134126113671491
nedostatku3401190029814126640954764973686294810791218
železa160611900298113238305430543671
v232511900298127
těle25011190029888213280406
PharmDr.3401590013764127186227322399441464
Marek8271590013793151193252312
Lapka,11611590013757116182242301330
Ph.D.15131590013764128157235261
Ústav3401740013371113150203254
farmakologie617174001333285121212265316374400461522548602
3.1243174001335678
LF13441740013352104
UK,14721740013371130156
Praha1651174001335993146206259
Nedostatek3402250012166117174229268302351383433480
železa843225001214393117167211260
(ID)1127225001212851117144
je1294225001212475
jednou1392225001212475132187242298
z17132250012143
nejčastějších17772250012155106130175223262296345369408431476531
nutričních23312250012156110144176200244299322367422
deficiencí27762250012157107137163208231281337382405
na32042250012155103
světě,3331225001213988137171220240
často3594225001214594133167221
vedoucí340239001214795150204257301322
k6792390012146
anémii7442390012147101150231253275
a10352390012148
dalším11022390012155102124162184265
zdravotním1383239001214297128175220272303357379460
komplikacím.1859239001214698180234257279324372415437518538
Tradiční2414239001214874121176198241294316
perorální27462390012156106137190222269291344366
železo3129239001214290113161203256
má34022390012181128
nízkou3546239001215476118163215269
biologickou340253001215780135159214271294339385439494
dostupnost8522530012156111150184239296351406445479
a13492530012148
způsobuje14182530012143100155194249306362385436
gastrointestinální18722530012155103142176209263286342374423462496519574622646701724
problémy,2614253001215689144201225275358404420
což3052253001214598140
snižuje3210253001214095118160215239289
ochotu35172530012155101155210243298
pacientů3402670012157106150173224279312366
pokračovat7322670012157113160194242287341388436469
v12262670012148
léčbě.1296267001212374119176226246
Sukrosomální15672670012149104151185239279334417466489544567
železo2160267001214292116167210265
(SI)245026700121287598125
představuje2601267001215790139197236270319365421445495
inovativní3121267001212479134181229262285333389413
formu3559267001212984117201256
perorálního3402810012157107140194226274297352375431486
železa844281001214292115165208257
s11192810012139
vylepšenými1179281001214898122172228267317372417501523
farmakokinetickými1720281001212977110193240287340387411466516549571616662712795818
vlastnostmi,2556281001214771119157191246300339373455478498
vyšší3072281001214798137175198
snášenlivostí3287281001214094142181230286309331379433471505528
a3402950012148
lepší409295001212373130168191
absorpcí.6182950012148104143197230287332355375
Tento1011295001214993148180233
článek1262295001214467115169219266
poskytuje15462950012156112150197247283337360410
komplexní19742950012146100183239263312359415437
přehled2429295001215789138194217267323
preklinických2770295001215689138185210233287310354400450494548
a33362950012148
klinických340529500121477194149171216262312355410
studií340309001214074130187211234
hodnotících6033090012156112170226281315338383407452508
účinnost11393090012156101125181236292332366
a15343090012149
bezpečnost16043090012158109153211263309365420460495
SI2127309001215073
v22293090012149
různých2300309001213389132188234279335
klinických266330900121487396152176221268319364419
situacích,311130900121406397152201246270315371392
včetně3532309001214892142176232283
těhotenství,340323001213383139195228278334373407458483504
onkologie,8723230012155112159213237293350374424444
nefrologie13453230012156107137171226250306363386437
a18113230012148
gastroenterologie.18813230012156104144178211266317374406456489544569624681705756776
Sukrosomální26863230012149104151186241280336420469493548572
železo3286323001214394118169212268
může35823230012184139182233
být3403370012157103140
dobrou5073370012157112169202257312
alternativou847337001214871104154187242290323346394448503
k13783370012147
intravenóznímu1446337001212479111144192239288344399440496519602657
podání21313370012157113170218273296
železa2455337001214393117167211260
a27433370012148
je2813337001212474
vhodné29153370012148104159216272322
pro3265337001215790144
pacienty,34373370012157106151174224280312362378
kteří340351001214783132165188
nesnášejí5493510012156106146201249288338362385
běžné9553510012157108151207257
perorální12333510012157108141196229277301356379
přípravky1633351001215790113170203251298345396
železa.2050351001214393117167210260281
Klíčová340368001246190118163221273326
slova:683368001244372130182235261
nedostatek9613680012155106163218257291340372422469
železa,1448368001214393116167210260281
anémie,17473680012148103154237260310330
sukrosomální2095368001214094141175230269324407456479534557
železo,2670368001214393117167210265284
perorální29723680012157108141196228277300355378
suplementace,3368368001214094151175225309359415340382001213382127176196
farmakokinetika,557382001212978111194242289343390415470521554577624673694
biologická1272382001215781136160215272295339386435
dostupnost.17283820012157112151185240297352407447481502
Sucrosomial3404100012454112158197255299357444472525553
iron913410001242866125184
–11174100012450
a11874100012453
new12604100012459112188
way14694100012475129179
to1668410001243795
address17844100012452112173212265309353
iron2157410001242866125184
deficiency23614100012460113148177223251304364410465
Iron340427001212457111167
deficiency5344270012157107137163208231281336381431
(ID)993427001212851117144
is1164427001212463
one12544270012155111161
of1443427001215584
the1554427001213388139
most17204270012184139178212
common1960427001214498182265320376
nutritional23634270012156110143176200233256311366414438
deficiencies28284270012157107137163208231281337382405455494
worldwide,33504270012173128160184241315338395445465
often340441001215584121171227
leading595441001212474123180203258315
to938441001213388
anemia10544410012149104155239262310
and13934410012148104161
other1582441001215588144194228
health18384410012156106155178212267
complications.2133441001214599183240265288333382414438493549588610
Traditional2771441001215077126183206239263318374422446
oral3245441001215589137161
iron3434441001212456111167
supplementation3630441001214094151340455001215781131215265321353402435458513569
using931455001215594117172228
ferrous1181455001213080113146200256295
and14984550012148104160
ferric1680455001213080113146169214
salts1916455001214089112145186
is2124455001212463
associated2209455001214887126182227250298330380437
with2668455001217498131186
low2876455001212479152
bioavailability3050455001215780135184231279302325373430454477500533583
and36554550012148104160
gastrointestinal3404690012156105144178211266290346378428468502525581629653
side1022469001213963120170
effects,1221469001215080113164210246287308
limiting1558469001212346130154187210266322
patient19094690012157106139163213269302
adherence22404690012148105161212245295351397446
to2715469001213387
treatment.2831469001213366116165198281332389421443
Sucrosomial33024690012150105150183238278333417441489513
iron340483001212356110166
(SI)53348300121297598126
represents686483001213282139172222262312368400441
an11544830012148103
innovative1284483001212479134189236285317340389438
form1749483001212984117201
of1977483001215584
oral2088483001215588136160
iron2275483001212356110166
with2468483001217497130186
improved26814830012123106163196250297347404
pharmacokinetic31124830012157113161193277325370424471496551601635658703
properties,340497001215790144202253285321344395434455
higher814497001215679134190240273
tolerability,1106497001213387111161194243299323346369402452468
and15934970012148104160
better17724970012157108141177226259
absorption.20504970012148104144199232289322345400456477
This25464970012150106129168
article2733497001214881117140184208258
provides3010497001215790144191215272322362
a33904970012149
comprehensive34604970012145981822392723213405110012155106162201224272321
review679511001213383131154205278
of975511001215584
preclinical1078511001215790140185208231287310354403427
and15235110012148104160
clinical170251100121446891146169214262286
studies2006511001214074129185208259298
evaluating2323511001215097146169224272304328383439
the2780511001213389139
efficacy2937511001215180113139184233277327
and32835110012148103160
safety3461511001214089118168201251
of3731511001215584
SI340525001214972
in440525001212379
various546525001214897129153208263302
clinical87652500121456891146169214263286
settings,1190525001213990123159182237293332353
including1571525001212378123146201258281336392
pregnancy,1991525001215790139196251299355400449465
oncology,24845250012155111156209233288345393409
nephrology,29215250012155105163219251305330385441489505
and34545250012148103160
gastroenterology.36415250012156104144340539001213366120171227259308341396420475532579596
SI954539001214972
may10445390012183132177
be12395390012157108
an13655390012148103
effective1486539001215180113163209244267315365
alternative1869539001214871104153186242290323346394443
to2330539001213387
intravenous2435539001212479111144192239288343398454493
iron2946539001212356110166
and31305390012148103160
offers3308539001215584117167200240
a35665390012148
new36365390012155106179
option3405530012155112145168223279
for640553001212984117
patients7785530012157106138162212267300340
intolerant1140553001212378110165189239272320376408
to1569553001213387
conventional1677553001214599155201250306338361416472520543
oral2242553001215487136159
iron2422553001212456111167
supplements.2610553001213994150208232282366416472504545566
Key3405700012461113165
words:5325700012476133172232276303
iron862570001212356111166
deficiency,10575700012156107137163208231281337382432448
anemia,15335700012148104154238261309330
sucrosomial1891570001214095140172227266322405429477500
iron,2419570001212456111167188
oral2635570001215588137160
supplementation,2823570001214095151209233283367418473506555587611666722742
pharmacokinetics,359457000121571131611933405840012183131176230277302357408441464509550571
bioavailability.932584001215781136184231279302326374430454477500533583600
Úvod3406330014780142208279
Globální480650001095880130182227248298319
data817650001095094124168
z10036500010938
celkem1060650001094185107149194269
1871347650001094688133
zemí1497650001093984160181
odhalily,16966500010949101151195216237259302316
že340664001093986
anémie453664001094496143221243290
postihuje7706640010952104141173195247298321368
až1164664001094585
jednu1276664001092270123175226
třetinu1529664001093061107139161213264
celosvětové1819664001094287110162340678001093680125155204247291
populace,6486780010951102153204225269309354372
ačkoli1037678001094384126174196218
prevalence1271678001095181126170214235281331372417
se1704678001093681
v18026780010943
jednotlivých18646780010922671193406920010950100130151172216262302352
regionech712692001092974126147197247293335385
značně1117692001093889132173223268
liší14056920010922437899
a15246920010944
nedostatek1587692001095095147197233264308338383425
železa340706001093984106151191236
(z601706001092664
anglického685706001094393144165186227269314364414
iron1125706001092150100150
defficiency;1301706001095096123153177217238284334375420439
ID)1766706001092182106
byl1897706001095193116
odpovědný3407200010949101153203246291343393434
za799720001093984
50908720001094692
%10257200010971
případů1122720001095181102154198249299
anémie.1446720001094394139215236282300
Studie1771720001094573123175196241
Global340734001095880130181225246
Burden602734001094999128179224274
of892734001094976
Disease984734001095981116161205240286
Study1286734001094472122173216
20161518734001094691133175
ukázala,1709734001094992136175220241285304
že340748001093986
anémie453748001094496143221243290
způsobená770748001093992144181232286333385430
nedostatkem1227748001095198152203240272318348392438516
železa1769748001094086109156197244
(IDA)340762001092647108162187
je553762001092269
čtvrtou648762001094073119150183233284
hlavní958762001095072116159210232
příčinou1216762001095282104145166217267318
zdravotních1560762001093991121166208258288339361402452
problémů,340776001095283134188210258335386406
zejména773776001093986108186233285330
u11297760010951
žen1200776001093986138
(1).136577600109266989107
Proto1499776001094979130161211
se1737776001093683
profylaxe1847776001095283134214063600109267294138181225
a23916360010943
management24536360010975119169213263309385430481510
ID2989636001092182
ukazuje3096636001095092137176226248294
jako3415636001092265108156
jeden3597636001092267119165215
z21406500010939
hlavních2198650001095071115157208229269319
zdravotních2536650001093990120164206255285335356397447
problémů3002650001095181130182204250326375
světa3396650001093680125155200
(2).361565000109257094111
Prevalence2280664001094877122165209230275326366411
a27076640010943
důsledky27696640010951100136157202254296342
ID3127664001092182
se3225664001093581
mohou33226640010975125175225275
značně36136640010938881321722140678001095097
lišit226367800109214379100131
v24206780010943
závislosti2483678001093985128150186208259295326348
na2857678001095094
konkrétním2977678001094392144187218264295346368444
klinickém344767800109426687138160201244289365
prostředí2140692001095079128162192221265315336
(3).249169200109256890107
Po2613692001094794
diagnóze2722692001094970112162210259296340
ID3077692001092180
je3172692001092266
obzvláště3253692001094999136181202244279309352
důležité3620692001095098119163214070600109385887131
najít2286706001094991112132161
a24627060010942
řešit2522706001092973107128157
základní2693706001093882123145187237286306
příčinu,3014706001095079100139159208256274
zejména3303706001093882103176221270312
v36307060010942
nevysvětlených36907060010949932140720001094387122166209239259304353393432481
a/nebo2636720001094274121165216265
recidivujících2916720001092973114134184205247297317338377398437486
případech,3417720001095079100150193244288329377396
a21407340010945
také2205734001093177121168
zvolit2400734001093987138161184215
terapeutickou2642734001093177109155208256308340362405449499551
možnost,32217340010977129169221273310343363
která3611734001094478124156201
bezpečně2140748001095196135186232273322367
odpovídá25237480010949100151201243264315358
potřebám28967480010951101131160204255299373
pacienta3285748001095194135155200250279323
(4,362374800109266987
5).372674800109466986
Nedostatek22807620010961109163215253285332363410455
železa2764762001093987110158199246
lze3039762001092263110
léčit3178762001092270113136168
perorálním33757620010952101132184216262285337359438
železem,2140776001093984106151191236312331
intravenózním2492776001092172101131175217262312362400450472547
(IV)306077600109264798126
železem3207776001093984106152191237312
a/nebo3541776001094375123169221271
DECLARATIONS:4072226008648871301662142563043393604124625014574227008514
Declaration407124000874987120141179207245272292334376
of446124000874166
originality:45412400087406888131151193231252272299338358
The407125100853473109
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been516425100853975110149
published532425100854078118135151178217252292
or407126200853862
submitted414826200852867108167184208234269310
elsewhere.44732620085355381117169209246269305320
Ethical407127600873764107127160198219
principles43042760087427090132165185229249288319
compliance:463827600873172134177198218256298331369388
The407128700853678116
authors420828700853475100142183208238
attest44672870085356087124154179
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by407129800854073
the41612980085236399
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Committee465129800854179139198215239265300337
and500429800853474114
is513529800851745
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compliance526929800853270130170188205239279311347
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human423930900854081143180221
studies44893090085285496139157195226
and474330900853577119
animal48913090085347695156193212
welfare513130900855391110133170196233
regulations53933090085236110414516420140713200085234080120148
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authors’44373200085347397136176200229244
institutions47013200085175684109126150189214231270310338
as505932000853462
well514132000855187105122
as528332000853362
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the55173200085236399
World407133100856099124142184
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Association453833100854474104144178196231256273314355
Declaration491433100854785119136172196232257274315356
of529133100853961
Helsinki537233100854785103132150190225244
on407134200853878
Ethical41683420085345898115147182199
Principles43863420085376178117150167207225261290
for46943420085216084
Medical479734200855693134151183218235
Research505134200853874102139173197229268
Involving53383420085165690128146181198238278
Human407135300854685145179219
Subjects431035300853474114132168201227256
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