691
Angelini15667710013061115168221244270324349
Pharma19357710013059113164201284335
Česká22907710013060114161211261
republika2571771001303689144198253276301351401
s.r.o.2992771001304876113137189216
Palachovo15667830013059110133184236290344389442
náměstí20287830013054105188240288324345
5,2393783001305178
62524917830013051105156
0026677830013057113
Brno,2800783001306399153207233
www.angelinipharma.cz156679500130721442162402913453984514745005545796356887397768599109379871032
24-12-E3-264935756811647129927547695122143172199221244273302330357
TRITTICO36051800124357493127162181217260
AC;63851800124377389
TRITTICO74451800124347493127162181217260
PROLONG:1021518001243978122154196238280295
S:1333518001243752
Trazodoni140251900113325486113149186223260277
hydrochloridum1699519001133867104128163193230249285309326363400454
752173519001132859
mg,2252519001135487102
150mg237451900113265893147179
v25745190011330
126245190011326
tabletě267051900113225693112146168201
s28915190011329
řízeným294151900113234067101138168222
uvolňováním.3183519001133767104122159196226260297314368381
Trazodoni358451900113325487113150187223261278
hydrochloridum3882519001133766103127163193230248285308325363399454
150435651900113265793
mg,4469519001135486102
3004591519001133166101
mg4712519001135587
v48195190011330
148695190011327
tabletě491651900113225693111145167201
s51375190011329
prodlouženým518651900113376196133152188225252286323352407
uvolňováním.360528001133767103122159196226259296314368381
I:754527001241934
Léčba80052800113316393130164
depresivních977528001133771108132165194211241279296326363
poruch135352800113377497134164201
u15685280011337
dospělých.1618528001133774103140174193222252289302
KI:193452700124415975
Přecitlivělost202252800113365992122139161180197227261280316345367
na2403528001133771
účinnou248752800113376784121158195232
látku273252800113195275106143
nebo2888528001133771108145
pomocné3046528001133773128164194231266
látky,332552800113195274105135146
intoxikace348452800113175577112142159190224254287
alkoholem378452800113345384120157194213247301
nebo4098528001133772108145
hypnotiky.4256528001133767104141177199216248278288
Akutní4558528001133667104126163180
infarkt475152800113185575109132164186
myokardu.4950528001135484120151185209245282295
ZU:525852700124357691
Pacienti536752800113366898115149187209226
s3605360011329
rizikem4105360011324416885116150205
sebevražedných635536001133064101135165189221248282319356386416453
myšlenek,1109536001135483112131165202236267281
sebepoškozováním1411536001132963100134171207237268304331367397431468485539
a19715360011334
sebevraždy,2026536001132964100135165188221248285315325
především237253600113376194131165195224241296
na2688536001133872
začátku278053600113276191125147178215
léčby,301653600113185282119149159
po3196536001133774
změně3290536001132781116153187
dávkování3498536001133771101132168198232269286
a38055360011334
zejména386053600113276178132167204238
mladí4119536001135473106143161
dospělí4301536001133773102139173192209
do4531536001133774
254625536001133162
let,47085360011319537588
musí4817536001135491120137
být497553600113376789
pečlivě5085536001133671101119136166201
sledováni.530653600113304882119156186219257274287
Je360545001131953
nutné43254500113387496134168
dávkovat619545001133771101132169199232254
s8935450011329
opatrností942545001133673107129153190226256278295
a12565450011334
pravidelně131054500113376093123140177211230267301
monitorovat1631545001135491128145167203226262292326348
pacienty1998545001133770100118152189211241
s22585450011329
epilepsií,230754500113347188107141177207224242255
hypertyreózou,2581545001133867104138162184213237270307333370406420
poruchami302054500113377497134164201235290307
močení,3346545001135591121155192209222
akutním3588545001133465102124161178232
glaukomem384054500113325185121153189243278332
s41915450011330
uzavřeným424054500113376498128151185222251305
úhlem,456554500113377493126181194
zvýšeným477954500113265686115149187216270
nitroočním506954500113375476100135172202239256311
tlakem539954500113224174106140194
a3605530011334
hepatálním,416553001133771108142164198216253270325338
renálním77655300113245794128146183201255
nebo1053553001133771108145
kardiálním122055300113316488124141175194231248302
onemocněním1544553001133774108162199229266300338355409
(včetně197555300113215181114136173208
prodloužení220555300113366096133151187224251285322339
QT2566553001134474
intervalu),266255300113175476110133164197215252273286
pacienty2970553001133771101118152189211241
současně3233553001132966103133166196233267
užívající352255300113376481111144162179209226
antikoagulancia377055300113347294111142178212244281299333370400417451
nebo4243553001133872109145
antiagregancia.441055300113347193110144177201234266300337367384418432
U48645530011341
starších492755300113305286109138155185222
pacientů5171553001133770100118152189211248
může5441553001135491118152
častěji36056200113306493115148166183
docházet567562001133773103140174201235257
k8485620011331
ortostatické90356200113376183119148170204226243273304338
hypotenzi,1265562001133767104140162196233260277290
somnolenci1579562001132966120157194212246283313331
a19345620011333
anticholinergním199256200113347193110140177214232249286321344376413430484
účinkům250056200113376784122153190244
trazodonu.276856200113224679105142179215252289303
V30955620011334
případě315356200113376178115149186220
výskytu339756200113306089120150172209
„flu-like“36305620011324426197123142159190224247
syndromu390156200113295996134157193247284
(horečka,420956200113215894118151181213246260
bolest449356200113367391125155177
v46945620011330
krku)474856200113315586123143
se4915562001133064
doporučuje5003562001133774110147171208238274291325
sledovat535256200113294882119156185219241
hematologické360570001133771126160182218236272305322352383417
parametry.80057000113377195127182216238262292302
Pokud1126570001133671102139176
se1325570001132963
u14125700011337
pacienta1472570001133770100117152189211245
vyvine174057000113306090107144179
žloutenka,194257000113274581118140174211242276289
léčba225457000113195383119153
trazodonem243057000113224679106142179216253287341
musí2795570001135491120137
být295557000113376789
přerušena.306757000113376194118155184218255289303
Podávání3393570001133671108142172205243260
antidepresiv367657000113347193110147181218242275304321352
pacientům4051570001133770100117152189211248302
s43765700011329
psychotickými442957000113376696126163199221238268300329384401
onemocněními4853570001133774108162199229266300338355409426
může5302570001135592118152
vést547857000113306493115
ke360579001133165
zhoršení448579001132664100124152187224241
psychotických71157900113376696126163200222239269300330360397
symptomů.1130579001133060114151173208263300313
Během1465579001133973110144199
léčby168657900113195283119149
bipolární185857900113365390127145179203240257
afektivní213757900113345588120142159189226243
poruchy240357900113367397133163201230
trazodonem265557900113224679106142179216253287341
se3019579001132963
může3105579001135491118152
depresivní3279579001133772108132165195212242279296
fáze359757900113215481115
změnit3735579001132681115152169191
v39495790011330
manickou.4001579001135588126143173204240277290
V43145790011335
tomto4371579001132258112134170
případě456457900113366077114148185219
musí4805579001135592121138
být496557900113376789
léčba507657900113195383120153
trazodonem525257900113224678105141179215252286341
zastavena.36058700113276190112146176210247281294
Možnost673587001134986112149186215237
vzniku92958700113305794111142179
serotoninového112658700113306488123145181218235273309339373410447
syndromu159158700113306097134158193247284
v18945870011330
kombinaci1943587001133167122158175213247277294
s22555870011330
dalšími230358700113377190119136190208
serotonergními252958700113296487123145181218252276307345362416433
látkami298158700113185274105139193210
a32105870011334
neuroleptiky.3263587001133771108132167186220256278295327357367
Přípravek364958700113365976113136169199233264
by3932587001133766
neměl4017587001133771126160179
být421458700113376789
podáván4321587001133774111145174208245
dětem458558700113377193127181
a47855870011334
mladistvým4837587001135573107144161190212242272326
do5182587001133774
185274587001132761
let535458700113185274
věku.544758700113306495132145
Obsahuje360596001134481110144181218235270
sacharosu.64459600113296393130164188223253290303
Pacienti96159600113366898115149186208225
nemají1200596001133872126160177195
řídit14095960011324417895117
a15405960011334
obsluhovat1588596001133774103121158195232262296318
stroje,192059600113295175110127162174
pokud2108596001133773105142179
se2301596001132963
u23785960011337
nich242959600113375484121
projevuje256459600113376196114148178215232266
ospalost,2844596001133766103136155191220242255
sedace,3113596001133064101135165199211
závrať,333859600113276191114147169182
stavy353459600113305286116145
zmatenosti3693596001132781115137171208245274296313
nebo4020596001133772108145
rozmazané417959600113245985140174200234272306
vidění.449959600113304784118155173186
NÚ:469959500124428499
Ospalost,4812596001134474110144162198228250263
závratě,508959600113276191114147169203215
nervozita,531859600113377295125162188205227261275
únava,360604001133774108138171185
cefalgie56760400113306384117135168185219
a8086040011334
nespavost,864604001133872101138171201238267289302
sedace,1188604001133064101135165199211
neklid,1421604001133772103121138175189
snížená163260400113296683110144181215
pozornost,1869604001133774100137160198234263285299
nauzea,2190604001133771108135169202216
zácpa,242860400113266090127161174
průjem,262460400113376197115149203216
dyspepsie,286360400113376795132166203232250284296
ovlivnění318260400113366685102132169203240257
chuti3462604001133067104126143
k36276040011331
jídlu36806040011317357291128
a38306040011334
tělesné388660400113225574108137174208
hmotnosti,4117604001133791128150187223253275292305
poruchy444460400113377397134164201231
hepatálních4697604001133771108142164198216253270300337
funkcí,505660400113215895126156173186
xerostomie,526460400113306488123152174210265282316329
serotoninový36061300113296487123145181218235272309339369
syndrom,74561300113305997134158193247261
ortostatická102261300113376183119148170204226243273304338
hypotenze,1377613001133766103139161195232259293306
poruchy169961300113377497134164202231
močení.1947613001135491121154191208222
Myalgie,2185613001135080113132164181215228
artralgie,243061300113345880103136154187204238251
vyrážka,269761300113316084117144175209222
pruritus.293661300113366097121138160197226239
IT:319261200124195366
Sedativní3275613001133469106140162179209246263
účinek355561300113376784121155187
antipsychotik,375861300113347294111147177207236274310332349380394
hypnotik,4169613001133766103140177199216247260
sedativ,4446613001133064101135157174204215
anxiolytik4677613001133472101118155173203225242273
a49676130011334
antihistaminik501861300113337193110147164193215249304321358375406
může5441613001135491118152
být36062100113376789
zvýšen,47262100113275787116150187200
v6966210011330
těchto75062100113225585122145180
případech95462100113376078114148185219249286
je1264621001131751
doporučeno1339621001133774110147171208238271308345
snížení170762100113306784111145182199
dávky.1930621001133771100132162172
Metabolismus2126621001134983105139176213231248278332369398
antidepresiv254862100113347193110147181218242275304321352
je2923621001131752
zrychlován299862100113275181110148166202232266303
perorálními332562100113377195130154187205242259313331
kontraceptivy,3679621001133168105127151183213247284306323353383393
fenytoinem,409662100113215491121143179196233267321335
karbamazepinem445462100113316589126159214248274308345362399434488
a49666210011334
barbituráty.502362100113377194131148170207231264286315326
Některá5373621001134377108130164187220
antipsychotika36063000113347193110147176206236273310332349380414
metabolismus788630001135589111145182218237254283338374404
antidepresiv120663000113347294111148182219243276305322352
inhibují.157363000113175491108145182199217230
Tricyklická181863000113325471101131162180197227259292
antidepresiva212563000113347193110147182218242275305322352385
se2525630001132964
nemají2603630001133872126160177195
podávat2813630001133773110144174208230
souběžně3057630001133066103140174200238272
s33446300011329
trazodonem.338863000113224678105141178215252286341354
Je-li37576300011318537897114
trazodon388663000113224578105141178215252
podáván4153630001133673110144174207245
se4412630001133064
silným449163000113294665102131185
inhibitorem469163000113175492109145163185220244277332
CYP3A4,5037630001133668105134170202216
měla5267630001135589107141
by5423630001133766
být550463000113376789
zvážena36063800113275790117151188222
nižší59863800113385581111128
dávka742638001133771101132166
trazodonu.92463800113224578105141178215252289302
Je1242638001131953
však131163800113305993124
třeba,145163800113224679116150163
kdykoliv163063800113316898129166184201231
je1877638001131852
to1945638001132258
možné,2019638001135491117154188201
se2236638001132964
vyvarovat231663800113306090123147183213246268
společného2600638001133066103121155185223257294331
podávání2947638001133673110144174207244262
trazodonu322563800113224578105141178215252289
a35306380011334
silných358063800113294665102132161199
CYP3A43795638001133567104134170202
inhibitorů.401363800113175491108145162184220244280294
Pokud4323638001133671102139176
je4515638001131751
trazodon458363800113224578105141178215252
podáván4851638001133773110144174208245
spolu5112638001132966103121158
s52866380011329
přípravky533163800113376178115139171201232262
obsahujícími360647001133773103137174211228246276293347364
třezalku74364700113224679105139157189225
tečkovanou,98764700113225586117153183217254290327341
nežádoucí134664700113377298132169206242272290
účinky165464700113376784121152182
mohou1855647001135491128165202
být207564700113376789
častější.218264700113306493115149166195212226
Podání2426647001133771108142180197
s26416470011330
antikoagulancii268964700113347193111142178212244281299333370400417434
a31426470011334
antiagregancii319564700113347193110144176200233266300337367384401
vzácně361564700113305690120158192
zvyšuje382564700113275787116153170204
riziko40486470011324416885116152
krvácení.421964700113315585119149182219236250
V44876470011335
průběhu454164700113376097134168205242
léčby480264700113185282119149
trazodonem497064700113224578105141178215252286341
by5329647001133767
neměl5414647001133872126160179
být36065500113376789
požíván470655001133773100117147180218
alkohol.70965500113345283120157193212225
TL:95665400124356783
Data106065500113407496130
dokazují,1211655001133774105139165202219237250
že1483655001132660
trazodon156565500113224678105141178215252
nemá1838655001133872126160
žádné202065500113266097134169
vedlejší2210655001133064101120154171200217
účinky244965500113366684121152182
na2652655001133771
těhotenství274565500113225592129151184222251273303320
nebo3086655001133771108145
na3252655001133771
zdraví334565500113266387120149167
plodu353365500113375591128165
či3720655001133047
novorozence.3788655001133774104140164199226260297327361373
Při418265500113375977
kojení428065500113316785119156173
je4474655001131852
nutno454765500113377496133170
zvážit473865500113275791117134156
poměr4916655001133673127162185
risk/benefit.512365500113244170101134171205243277295313335348
Vliv549265500113355471101
na360664001133771
fertilitu45266400113205478100117135153175211
není684664001133772109126
znám.83066400113276498153166
D:1017663001244257
TRITTICO109466400113326987119151169204247
AC:136266400113367084
Obvykle1466664001134581111141172191225
75-150171266400113285884106137172
mg/den1905664001135486120154188225
v21516640011330
jedné220166400113185289126160
dávce2382664001133771101131164
večer256766400113306494128151
před273966400113376194131
spaním,2890664001133066100137154209222
lze313366400113184579
postupně3233664001133673102124161198235269
zvýšit352366400113275787116133155
(o3698664001132158
503776664001133267
mg3863664001135587
každý397166400113316591128158
3.-415066400113314467
4.den)423766400113344783117155175
na4433664001133771
3004525664001133166101
mg/den4647664001135487120154188225
ve4893664001133064
dvou4978664001133767103140
dílčích513966400113375473103120150187
dávkách.5347664001133771101132166196233246
U3606720011342
hospitalizovaných420672001133774103140157179213231248275311341375412441471509
lze94767200113184579
zvýšit104467200113275787116133155
na1217672001133771
6001306672001133469104
mg/den,1429672001135486120154188225238
v16856720011330
rozdělených173467200113245985122157175209246276305343
dávkách.2095672001133771101132165195233246
Doporučená2359672001134077114150174211241274312346
dávka2723672001133771101132165
pro290767200113366096
starší302167200113295185109137154
a31946720011334
oslabené324667200113366684118155189226260
pacienty3524672001133771101118152189211241
je3783672001131752
snížena385367200113296683110144181215
na4086672001133872
75-100417667200113285884106141176
mg/den.4371672001135486120153188225238
Po4627672001133771
dosažení4717672001133773102136163197234251
klinické498767200113314966104121151182216
odpovědi5221672001133774111147177211248265
má5504672001135589
být36068100113376789
dávka470681001133771100132165
udržována65668100113377498124160190224261295
alespoň97268100113345286116152189226
jeden121968100113175289123160
měsíc.1400681001135489118135165179
Je1600681001131953
doporučeno1674681001133773110147171207237271308345
pokračovat2040681001133673104128161191226256290312
v23736810011330
léčbě,242468100113195383119154166
dokud2611681001133774105142179
pacient2811681001133770100118152189211
nebude3043681001133771108145182216
4-6328068100113335892
měsíců3393681001135489118135165201
bez361568100113377198
příznaků.373468100113366077104141175206243256
Při401168100113375977
ukončení4109681001133668104141171205242259
léčby,438968100113195282119149160
zejména457068100113266178132166203237
po4828681001133774
dlouhodobější492368100113375592128166202239276313347364393410
léčbě,535468100113195383120154166
je5541681001131852
doporučeno360689001133774110147171208238271308345
postupné725689001133774103125162198236270
snižování101568900113306784111147177211248265
dávky.1301689001133771100131161172
TRITTICO149468900113316987119150169204247
PROLONG:1761689001133774118149190233273286
Počáteční2067689001133771101135157191221258275
dávka2362689001133771101132166
150254868900113275893
mg/den2662689001135487120154188225
může2908689001135491117152
být308068900113376789
zvýšena318968900113275787116150187221
o34316890011336
753488689001132858
mg/den3567689001135487120154188225
každé381368900113316591128162
tři399668900113224663
dny4079689001133775104
až4203689001133461
do4285689001133773
maximální4379689001135488117135189223241278295
dávky4695689001133771101132162
3004877689001133167102
mg/den.4999689001135587120154188226239
V52586890011335
některých5314689001133771102125158182212242279
případech36069800113376178114148185219249287
lze66169800113194680
počáteční756698001133773103137159192222259277
dávku1047698001133871101132169
snížit123169800113306784110128150
na1396698001133771
751482698001132858
mg/den.1555698001135487120154188225239
Doporučená1824698001134077113150174211241274311345
dávka2184698001133771101132166
pro236569800113366096
starší247669800113295185109137154
a26456980011334
oslabené269469800113376685118155189226261
pacienty2970698001133670100117151188210240
je3225698001131751
snížena329169800113306784111145182216
na3522698001133771
753608698001132858
mg/den.3681698001135587120154189226239
Přípravek393569800113365976113137169199233264
se4214698001133064
podává4293698001133673110144174207
na4515698001133872
lačno460269800113185282119155
a47726980011334
zapije482169800113276198115132166
se5002698001133064
sklenicí508169800113296079113150167197214
vody,5310698001133067104134144
vždy546969800113305794124
jednou36070600113175188126162199
denně,576706001133771108146180192
večer.78570600113306595128152160
Po962706001133671
dosažení1050706001133773103137163198235252
klinické131970600113314967104121151182216
odpovědi1552706001133774110147177211248265
má1834706001135488
být193970600113376789
dávka2045706001133771100132165
udržována222770600113377498124160190224261295
alespoň253970600113345286116152189226
jeden278270600113175188123160
měsíc.2959706001135488118135165179
Je3154706001131953
doporučeno3224706001133774111147171208238271308345
pokračovat3586706001133773104128161191227257290312
v39157060011330
léčbě,396270600113195383119154166
dokud4145706001133774105142179
pacient4341706001133670100117151189211
nebude4569706001133771108145182216
4-6480270600113335892
měsíců4910706001135589118135165202
bez512970600113367197
příznaků.524370600113376077104141175206243257
Při551670600113375977
ukončení360715001133768104142172205242259
léčby,63871500113185282119149159
zejména81571500113276178133167204238
po1071715001133774
dlouhodobější116371500113375592129166202239276313347364393410
léčbě,159271500113185282119153166
je1776715001131751
doporučeno1845715001133774111147171208238271309345
postupné2208715001133774103125162199236270
snižování249671500113296784110147177210248265
dávky.2779715001133771101132162173
Neexistují2970715001134377111140158187209246263281
žádné326971500113276198135169
důkazy,3456715001133774105139166196206
že3681715001132660
by3760715001133666
byl384471500113376785
trazodon394871500113224578105141178215252
návykový.4218715001133771101131162199229259269
DRR:4505714001244281121136
Angelini4660715001133673106140159176213230
Pharma4908715001133772106130185219
Česká514571500113356897128162
republika532571500113245794131168186203234268
s.r.o.,3607230011329436674110123136
Palachovo51372300113376887120150187224254290
náměstí820723001133872126160189211229
799/5,106672300113285993123153166
625124972300113346495
001361723001133571
Brno,144972300113386299135148
Česká161472300113356898129162
republika.179372300113245794131168186203234268281
Reg.č.:2091722001243974110125155171186
Trittico22927230011332547193115132162198
AC2507723001133670
75:259472300113285972
30/504/99-C,2683723001133166100130165198230261294319355368
Trittico30687230011331537092114132162197
AC3282723001133771
150:337072300113275893106
30/505/99-C,3493723001133167100130165196228259292318353366
Trittico38767230011332547193115132162198
Prolong409172300113365994113149186218
150432672300113275893
mg:4436723001135587100
30/140/14-C,4553723001133167100122156191224247280305340353
Trittico49237230011332547193115132162198
Prolong513872300113365994113149186219
3005374723001133166101
mg:5493723001135487100
30/141/14-C.360732001133166100122155179212235268293328341
Uchovávání:726731001244272109146179213245279315333348
Při109973200113365976
teplotě120073200113225592111147169202
do1427732001133774
251525732001133162
°C,161273200113336982
v17197320011330
původním1774732001133673103140177214231285
obalu,2084732001133773107125162175
chránit228473200113306791124161178200
před250973200113376094131
světlem266473200113306094116134168223
a29117320011334
vlhkostí.297073200113304986117154183205222235
Datum3230731001244276101137191
poslední3442731001243875106125160198235253
revize371673100124256092110139174
textu391173100124255991116152
SPC:4084731001243775112127
Trittico42337320011332547193115132162198
AC:445573200113367184
12.5.2023,456473200113275770102115146181211242255
Trittico48447320011332537193115132162197
Prolong:506673200113375995113149187219232
11.12.2024.53237320011326526585116129160195225256270
Přípravek36074000113365976113137169199233264
je642740001131752
vázán71174000113316491125162
na891740001133771
lékařský98074000113195284117141169201231
předpis122874000113376194131168185214
a14607400011334
je1512740001131751
hrazen158174000113376194121155192
zdravotními179174000113276387120150186208245262317334
pojišťovnami.214374000113367390107137159194224261295350367380
Seznamte254174000113346995132166221243276
se,283574000113296376
prosím,292974000113376096125142197210
se3157740001132963
Souhrnem3238740001133571108145169206241295
údajů3551740001133774108125162
o37307400011337
přípravku378574000113376078114138171201232269
(SPC).407174000113215692127148161
Trojí325033700486166257393467558
účinek389333700486167289386556683831
pro233837800486161276412
maximální283537800486194345473562756907100911791270
spokojenost4190378004861112724175667077819141086122613341446
vašich242541900486117272380474593754
pacientů3264419004861613144355336648369391099
s444841900486111
depresí464441900486170300461576699810904
Antidepresivní,23304740024791181228276361426508566629686733792878925967
anxiolytický,33404740024777163228273347396458509557617694754782
spánek41654740024756138216302367442
normalizující46514740024786157214312388440487553636674720780830